Penicillin in Typhoid Fever

in the temperature and his condition did not improve. Other bacteriological examinations such as cultures of blood, urine and faeces were not practicable but because the results of therapeutic tests were negative and typhoid fever is endemic in the locality my suspicion was strongly in favour of an acute onset of typhoid fever. On and from the 7th day of the disease he was going bad. His temperature ranged between 103?F. and 105?F.; pulse was 102 and respiration 30 p.m. Lungs were clear. He became cyanosed, a little dyspnocic and drowsy. There was a good deal of flatulent distension, heart in fibrillation.